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NAKFI Imaging Science Grantee Publishes Two Papers


NAKFI’s Imaging Science Grant “Building multiscale models of capillary regeneration from image-based RNA transcriptome analyses” has resulted in two publications.   Principal Investigator and NAKFI Imaging Science Conference Attendee, Amina A. Qutub, and her collaboraters have published some of their results in The Journal of Theoretical Biology and Angewandte Chemie International Edition.  Dr. Qutub is an Associate Professor in Bioengineering at Rice University.  Additionally, Dr. Qutub is a researcher in the BioScience Research Collaborative at Rice University.As a result of NAKFI’s Imaging Science Grant “Building multiscale models of capillary regeneration from image-based RNA transcriptome analysesDr. Amina A. Qutub and her collaboraters published a paper in The Journal of Theoretical Biology and an additional paper in Angewandte Chemie - International Edition. 

 

In the first paper, one of the collaborators on the grant, Mike Diehl, developed a multiplexed imaging technique that allows us to visualize dozens of fluorescence probes on a single sample, using a traditional 3-color microscope.
 
In the second paper, they introduce an innovative computer framework to design new human capillaries.  Together, these two technologies are being integrated in a way that is beginning to allow us to 'control' or program cell behaviors and shapes - for applications to tissue engineering and understanding cancer.

 
“We're very excited with the applications of this work, and grateful for NAKFI for providing the seed-funding to kick-start it!” – Dr. Amina A. Qutub
 
To access the articles please click on the links below
 
R. Schweller, J. Zimak, A.A. Qutub, Hittleman W.N., Diehl M.R. (2012) Multiplexed In Situ Immunofluorescence via Dynamic DNA Complexes. 
Angewandte Chemie 51: 9292-9296.
http://onlinelibrary.wiley.com/doi/10.1002/anie.201204304/abstract
 
B. Long, R. Rekhi, J. Jung, A. Abrego, A.A. Qutub (2012) Cells as State Machines: Cell Behavior Patterns Arise during Capillary Formation as a Function of BDNF and VEGF, Journal of Theoretical Biology, in press.
http://www.sciencedirect.com/science/article/pii/S0022519312006194